There are many ways in which human stem cells can be used in basic research, clinical research and medical practice.
Continued intensive research has been carried on in many different places in the world as to cell therapy.
As a stem cell is the one capable of originating and/or regenerating all cells, tissues and organs of the human body, their therapeutic potential is theoretically unlimited.
The first cord blood transplant occurred in 1988, when a 6-year-old boy received his sister’s cord blood and got cured of the hematological manifestation of Fanconi anemia. The boy is alive and in good health more than 16 years after that historical proceeding.
Today, more than 3,000 UCB transplants have happened all over the world.
Diseases treated with UCB: |
- Leukemias
- Burkitt’s Lymphoma
- Liposarcoma
- Myelodysplasia
- Neuroblastoma
- Hodgkin’s Disease
- Non-Hodgkin’s Lymphoma
- Aplastic Anemia
- Diamond-Blackfan Anemia
- Fanconi’s Anemia
- Megakariocytic Thrombocytopenia
- Kostmann Disease
- Thalassemia (Cooley’s Anemia)
- Sickle-cell disease
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- Adrenoleucodystrophy
- Batten Disease
- Hunter Syndrome
- Hurler’s Syndrome
- Lesch-Nyhan Syndrome
- Maroteaux-Lamy Syndrome
- Omenn’s Syndrome
- Thymus Dysplasia
- Globoid Cell Leukodystrophy
- Wiskott-Aldrich Syndrome
- Lynphoproliferative syndrome
- Evans’ Syndrome
- Osteopetrosis
- Histiocytosis of Langerhans’ Cells
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This list was compiled from recently published articles from the PUBMed and the book, Cord Blood: Biology, Immunology, Banking and Clinical Transplantation, of the American Association of Blood Banks.
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Heterologous (Recent Advances in Heterologous use of UCB) |
· 20 patients were treated with cord blood for Hurler’s Syndrome
New England Journal of Medicine, 2004, 351 (5):506-7 Kurtzberg J. et al.
“The use of cord blood altered the course of the pathology of the Hurler’s Syndrome and
must be considered an option in the youth with this type of pathology”
· 37 year old woman treated with cord blood for injury to spine
Cytotherapy, 2005, 7(4):368-373.
“Transplant of umbilical cord blood is a good option as a method of treatment for
patients with injury to spine”
· Patients treated with umbilical cord blood with Krabbe’s Disease
New England Journal of Medicine, 2005, 352 (20):2069-81 Kurtzberg J et cols
“The use of cord blood, in new-borns, positively altered the couse of the pathology.”
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Autologous (Recent Advances of Autologous use of UCB) |
· Autologous cord blood transplantation
E. Ferreira et Al. Bone Marrow Transplantation,1999, 24, 1041
A girl1 year 2 months old developed a stage IV neuroblastoma treated with autologous
placental blood transplant. She did very well and is in complete remission from her disease,
14 months post transplant, with a normal blood count.
· The Successful Treatment of Severe Aplastic Anemia with Autologous Cord Blood Transplantation
SM. Fruchtman et al.,2004 Biology of Blood and Marrow Transplantation 10:741-742
A report on the successful use of autologous cord blood transplantation for the treatment of
severe aplastic anemia following fulminant hepatic failure and living related liver transplantation.
· First Report of Autologous Cord Blood Transplantation in the Treatment of a Child With Leukemia
Ammar Hayani et al. 2007 Pediatrics ,119 (1):295-300.
3-year-old girl with acute lymphoblastic leukemia who developed isolated central nervous
system relapse while receiving chemotherapy 10 months after diagnosis. She then
her own umbilical cord blood. She is now underwent myeloablative chemotherapy and
radiation therapy followed by infusion of doing well and is in complete remission
20 months after cord blood transplantation.
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